The Skin Diary Age Defence Moisturising Day Cream 50 ml

Age Defence- The Everything Day Cream

Your ultimate protection against cellular ageing. Deeply nourishing all-day hydration with DNA repair enzymes, antioxidants and encapsulated sunscreen, restoring youthful skin function by helping prevent cellular senescence, inflammation and the breakdown of collagen and fibrillin.

Highlights:

• Lightweight, all-day hydration with a non-greasy finish
• Helps to repair UV-induced DNA damage
• Encapsulated broad-spectrum SPF50 | PA++++
• Dermatologically approved
• Prevents collagen and fibrillin breakdown
• Can be worn alone or under makeup
• Active protection against UV-induced molecular ageing and oxidative stress
• Scientifically proven to protect against UV-induced gene expression changes linked to cellular senescence, inflammaging and collagen breakdown
• Suitable for sensitive skin
• 50ml

Key Ingredient Technologies:

Encapsulated Sunscreen Filters

Protecting your skin from future UV damage is crucial to optimal ageing. Age Defence contains elegant broad-spectrum SPF50 PA++++ with encapsulation technology that shields without irritating the skin or feeling like a heavy traditional sunscreen.

DNA Repair Enzymes

Two types of DNA Repair Enzymes - Photolyase and Endonuclease - get to work identifying and repairing broken DNA strands caused by past UV damage, which contribute to chronic skin ageing.

Antioxidant Complex

Working synergistically with the encapsulated sunscreen filters, bilberry extract and raspberry seed oil provide polyphenol-rich antioxidant protection, scavenging free radicals that contribute to DNA damage through oxidative stress.

All-Day Hydration

Squalane, raspberry oil, glycerin and vitamin E provide all the hydration you need in your morning routine - lightweight and non-greasy throughout the day.

Clinically Proven Protection:

Age Defence was tested with advanced gene expression testing in 3D human skin equivalents to measure its true impact on epigenetic ageing, cellular senescence and oxidative stress. Research was independently carried out by Professor Mark Birch-Machin, Professor of Molecular Dermatology and widely recognised as a leading expert in UV-induced cellular damage to human skin and skin ageing.

The Results:

• Prevents UV-induced Cellular Senescence: Statistically significant protection against UV-induced P21 expression
• Prevents UV-induced Inflammation: Complete reduction of PTGES expression to baseline levels following UV exposure
• Prevents Breakdown of Collagen and Fibrillin: Prevents the UV-induced spike in MMP1

The Skin Diary Age Defence is proven for statistically significant protection against UV-induced epigenetic activity, supporting the role of the formula in modulating the skin's biological ageing pathways.

Apply to clean, dry skin every morning as the final step in your skincare routine. Can be worn alone or under makeup. Apply generously and evenly to face and neck. Reapply every 2 hours during prolonged sun exposure.

Encapsulated Sunscreen Filters: Broad-spectrum SPF50 PA++++ with encapsulation technology- shields without irritating or feeling heavy on skin.

DNA Repair Enzymes: Photolyase and Endonuclease- identify and repair broken DNA strands caused by past UV damage that contribute to chronic skin ageing.

Antioxidant Complex: Vaccinium Myrtillus (Bilberry) Extract and Raspberry Seed Oil- polyphenol-rich antioxidants that scavenge free radicals contributing to DNA damage through oxidative stress.

All-Day Hydration Complex: Squalane, Raspberry Oil, Glycerin, Vitamin E- lightweight, non-greasy hydration for all-day comfort.

About The Skin Diary: The Skin Diary is a dermatologist-developed skincare brand committed to delivering clinically proven, science-backed formulations that deliver real, measurable results. Every product is developed by world-renowned experts and held to the highest standards of scientific testing — including double-blind, placebo-controlled clinical studies and independent gene expression testing in human skin.

The brand was created with a clear mission: to bridge the gap between cutting-edge dermatological science and everyday skincare. Rather than relying on marketing claims, The Skin Diary invests in rigorous clinical validation, working with leading academic dermatologists including Prof. Chris Griffiths OBE and Prof. Mark Birch-Machin to ensure every formula delivers on its promises.

What sets The Skin Diary apart is their commitment to targeting the root biological causes of skin ageing — cellular senescence, DNA damage, collagen breakdown, and oxidative stress — rather than simply masking the visible signs. Their formulations are designed to work at a cellular and molecular level, delivering results that are measurable, reproducible, and scientifically verified.

South William Clinic is a trusted authorized partner of The Skin Diary, bringing you authentic, clinically proven products with full manufacturer support. Our medical facility ensures proper storage and handling of these dermatologist-developed formulations, while our experienced team provides expert guidance for optimal results.

When you choose The Skin Diary through South William Clinic, you're investing in skincare backed by world-leading dermatological research. Every product comes with our guarantee of authenticity and our commitment to helping you achieve transformative, science-driven skin health.

Q: What makes Age Defence different from a regular SPF moisturiser?
A: Age Defence goes far beyond standard sun protection. It combines encapsulated SPF50 PA++++ with two types of DNA repair enzymes (Photolyase and Endonuclease) that actively repair past UV damage, plus a polyphenol-rich antioxidant complex. It's clinically proven to prevent cellular senescence, inflammation, and collagen and fibrillin breakdown at a molecular level.

Q: What are DNA repair enzymes and why do they matter?
A: Photolyase and Endonuclease are two types of DNA repair enzymes that identify and repair broken DNA strands caused by past UV damage. These broken strands contribute to chronic skin ageing, so repairing them is crucial to maintaining long-term skin health and reversing the signs of ageing.

Q: What does "encapsulated sunscreen" mean?
A: Encapsulation technology wraps the sunscreen filters in protective micro-capsules, allowing them to shield the skin from UV damage without the heavy, irritating feel of traditional sunscreens. This makes Age Defence elegant and comfortable for daily wear, even on sensitive skin.

Q: What is cellular senescence and how does Age Defence prevent it?
A: Cellular senescence is when skin cells stop dividing and functioning properly, contributing to visible ageing. Age Defence was clinically proven to provide statistically significant protection against UV-induced P21 expression — a key marker of cellular senescence — helping to keep skin cells functioning youthfully for longer.

Q: What clinical evidence supports Age Defence?
A: Age Defence was tested using advanced gene expression testing in 3D human skin equivalents by Professor Mark Birch-Machin, Professor of Molecular Dermatology. Results showed statistically significant protection against UV-induced cellular senescence (P21), complete reduction of inflammation (PTGES) to baseline levels, and prevention of collagen and fibrillin breakdown (MMP1 spike).

Q: Can I wear this under makeup?
A: Yes, Age Defence is specifically designed to be worn alone or under makeup. Its lightweight, non-greasy finish makes it an ideal daily moisturiser and SPF base for any makeup routine.

Q: Is this suitable for sensitive skin?
A: Yes, Age Defence is dermatologically approved and suitable for sensitive skin. The encapsulated sunscreen technology minimises irritation, while the gentle antioxidant and hydration complex nourishes without causing sensitivity.

Q: Does this replace my moisturiser?
A: Yes, Age Defence provides all-day hydration through squalane, raspberry oil, glycerin and vitamin E, making it your complete morning moisturiser and SPF in one step. No separate moisturiser is needed in your morning routine.

Q: How does this prevent collagen and fibrillin breakdown?
A: Clinical testing showed Age Defence prevents the UV-induced spike in MMP1 — the enzyme responsible for breaking down collagen and fibrillin (elastin). By blocking this pathway, Age Defence helps maintain skin firmness, elasticity and structural integrity over time.

Q: Do you ship internationally from Ireland and what about customs?
A: Yes, we ship worldwide from our Irish facility. We regularly serve customers in the UK, United States, Germany, Italy, Spain, Cyprus, Australia, France, Netherlands, Canada, and many other countries throughout Europe, Asia, and the Middle East. Please note that customers are responsible for any local customs charges which are outside of our control.